Here's a much more exhaustive list, from the Caffeine Blues:
Coffee is one of the most heavily sprayed foods/ beverage commodities - if not organic, it is literally a cup of chemicals.
Caffeine increases blood pressure (hypertension) and stress hormone levels
One study documented significant increases in thought disorder and psychosis after caffeine administration.
Caffeine produces metabolic, biochemical and emotional stress
Caffeine causes blood sugar swings
Fatigue, sleep disturbances are often caused by a coffee/ caffeine habit
Fatigue, depression and brain fog can result from caffeine withdrawal
"... caffeine decreases learning skills in a number of ways. It constricts blood vessels in the brain, leading to marked reduction in cerebral blood flow, and interferes with brain biochemistry." (p. 288)
"A single 250-milligram dose of caffeine (the equivalent of about 2.5 six-ounce cups of coffee) has been shown to increase levels of stress hormone epinephrine (commonly known as adrenaline) by more than 200 percent." (p. 56, Caffeine Blues)
"...women consuming high amounts of tea suffered 80 percent more PMS [pre-menstrual syndrome]." (p. 321) "Women who consumed more than 4.5 cups of tea per day were almost 10 times as likely to suffer from PMS as women who drank none." (p. 242) "Basically, the more caffeine you consume, the worse your PMS will be." (p. 240)
Adverse effect on children's growth: "One recent study in Guatemala found that taking children off caffeine for just five months resulted in 22 percent gains in length compared to the group that continued drinking coffee." (p. 292, Caffeine Blues)
Caffeine contributes to irritability, anxiety, anger, headaches and nervousness.
Tiredness during the day, disturbed sleep
Caffeine causes increased loss of B vitamins (measured in the urine)
"One study demonstrated that chronic, heavy caffeine ingestion can be associated with depression and may also cause anxiety and panic in panic disorder patients [...] In a study of agoraphobia and panic attacks, caffeine consumption exacerbated anxiety in 54 percent of the patients and triggered panic attacks in 17 percent." (p. 243)
Menopausal hot flashes and their intensity is linked to caffeine consumption.
"Researchers at the University of California in San Francisco [...] found a significant association between caffeine consumption and reduced bone mass." (p. 232, Caffeine Blues)
Caffeine dramatically reduces iron absorption, contributing to iron deficiency.
Caffeine increases calcium loss and the risk of osteoporosis
Caffeine produces short-term mood elevation but contributes to rebound depression
"... caffeine contributes significantly to anxiety, hostility, and depression. In turn, these are powerful risk factors for irritable bowel syndrome and ulcers." (p. 229)
"...conclusive research has found a significant association between caffeine intake and miscarriage." (p. 229, Caffeine Blues)
Sleepiness, tiredness, feeling disorganized (this effect has been reported to be stronger on women than men)
"Caffeine causes a marked constriction [to the veins] that limits the delivery of oxygen and vital nutrients to the tissues [= to cells]." (p. 221) This constriction of veins affects the brain, peripheral blood vessels, and the eyes (e.g. glaucoma). Uric acid also causes the painful condition of gout.
"...one of the breakdown products of caffeine is methyluric acid, and that can add to the body's uric acid burden." (p. 220, Caffeine Blues) [High uric acid in the body (hyperuricemia) can cause kidney disease, among other problems.]
"Men can significantly reduce their risk for urinary and prostate problems by getting off coffee and caffeine" (p. 216)
"Recovery [from fibromyalgia] is unlikely as long as your adrenals are stressed. Avoiding caffeine will greatly increase your change of recovery"
"Any caffeine intake only worsens [Stage 4] sleep disturbance. [...] Anyone with disturbed Stage 4 sleep will have aches and pains from unrepaired microtrauma that occurs in the muscles and connective tissue." (p. 213)
Caffeine addiction can make asthma symptoms worse (the withdrawal from caffeine can cause an asthma attack, thus the faulty view that caffeine helps with this)
Exhausted adrenal glands - which caffeine contributes to in no small way - are unable to produce either sufficient DHEA or cortisol, and this double whammy sets the stage for autoimmune disease.
Mood disorders
Inflammation
"Caffeine raises blood sugar levels and disrupts the blood sugar-regulating effects of insulin [...] Caffeine raises fatty acid levels in the blood [...] and can significantly increase the risk of heart disease [...] Caffeine raises the homocysteine levels [...] Caffeine causes vascular resistance, in which blood vessels constrict and circulation is reduced. [...] Caffeine raises stress hormone levels [...] Chronic stress, including feelings of irritability and hostility, has been linked to the development of insulin resistance, leading to the diabetic state." (p. 199-200, Caffeine Blues)
Caffeine accelerates aging by impairing immunity
Caffeine has been shown to inhibit DNA repairs
The net effect of caffeine use is accelerated aging, especially of the skin and kidneys
Caffeine is a common trigger for migraine and other types of headache.
"Whether or not you suffer from tension or migrane headaches, you have to ask yourself if you want to consume a drug (caffeine) that clamps down the blood vessels of your brain and restricts oxygen delivery to millions of cells." (p. 189-190)
Caffeine increases tension in the jaw, shoulders, back and neck.
"In one study, individuals with chronic back pain were found to be consuming an average of nearly 400 milligrams of caffeine per day, while matched controls (people the same age and occupation without back pain) averaged less than half that amount." (p. 183)
"... the critical role played by melatonin in regulating immunity and sleep. I presented evidence that caffeine and coffee, especially when combined with other stressors, significantly reduce melatonin levels. And melatonin's effect on the GI tract [gastro-intestinal tract] is more than calming. Researchers believe that melatonin's principal role in the GI tract is to promote healing and boost immune defense." (p. 180, Caffeine Blues)
"In clinical practice, I saw hundreds of patients whose irritable bowel syndrome, colitis, food allergy, gastritis, heartburn, bloating, and abdominal pain improved or healed completely once they got off coffee." (p. 181, Caffeine Blues)
Coffee contributes to ulcer formation because of its harsh acids (which are even worse in decaf coffee). Caffeine itself stimulates acid secretion in the stomach and interferes with the protective action of GABA. This becomes even more of a problem if coffee is consumed on an empty stomach.
Caffeine and chronic stress elevate blood levels of cortisol, which suppresses a number of immune functions, including production of secretory IgA (sIgA), which is a powerful microbial agent. When sIgA levels are low, 'H. pylori' is allowed to proliferate and cause ulcers. When sIgA levels are high, H. pylori and other pathogens in the mouth, throat, and gastrointestinal tract are quickly destroyed. "When viewed in this way, H. pylori is actually a second risk factor. Stress, caffeine, elevated cortisol, and suppressed IgA production are the primary factors contributing to ulcer risk." (p. 176)
Coffee is the frequent cause of both constipation and diarrhea. Caffeine tends to pull water out of the digestive tract, leading to hard stools that are difficult to pass.
Coffee interferes with the digestion of protein
"Caffeine is one of those substances (along with refined sugar, 'fake fats', and hydrogenated oils) that is completely foreign to the human gastrointestinal tract." (p.168, Caffeine Blues)
Coffee raises homocysteine and lowers magnesium. The correct levels of these are critically important for someone high cholesterol and high blood pressure. Alzheimer's disease is also characterized by abnormally high homocysteine levels.
"Moderate coffee drinkers with high cholesterol had more than seven times the risk of heart attack, while heavy coffee drinkers had eighteen times the risk of non-coffee drinkers." (p. 162)
"... blood cholesterol levels appear to rise in direct proportion to the number of cups of coffee consumed, and we now know what causes this rise in blood cholesterol. It's not the caffeine, as once thought, but two other chemicals (diterpene alcohols) naturally found in coffee: cafestol and kahweol." (p. 144, Caffeine Blues)
"... the increased risk of heart attack was seen starting at one to two cups of coffee per day." (p. 161, Caffeine Blues)
Modest amount of caffeine taken before exercise produced dangerous elevations in blood pressure in 45 percent of subjects.
"If a person were injected with 500 milligrams of caffeine, within about an hour he or she would exhibit symptoms of severe mental illness, among them, hallucinations, paranoia, panic, mania, and depression. But the same amount of caffeine administered over the course of a day only produces the milder forms of insanity for which we take tranquilizers and antidepressants." (p. 124-125)
"Research has also found that caffeine ingestion is associated with lower academic performance and greater incidence of psychosomatic illness." (p. 120)
The caffeine-depression connection is very clear.
"... the feelings of tiredness and depression that come three hours after a cup of coffee are seldom associated with caffeine. We blame something else, like the weather or a boring job." (p. 111, Caffeine Blues)
"Coffee cuts you off from the brain's higher centers of reasons and evaluation because you are forcing your brain into defensive, emergency overdrive." (p. 95)
A single cup of coffee can reduce the iron absorption from a meal as much as 75 percent.
"GABA has a unique ability to calm the mind without putting you to sleep. [...] Caffeine, it turns out, disrupts the normal metabolism of GABA. Here's this wonderful brain biochemical that increases the 'filter mechanism' of the brain, helps you to step back and see clearly even under stress, and caffeine screws it up. Thus, in the maze of life you never make it to the cheese." (p. 70-71, Caffeine Blues)
Caffeine lowers the stress threshold in virtually anyone.
Caffeine elevates cortisol, which leads to DHEA (= a steroid-hormone) deficiency. DHEA levels are an indicator of the health of the adrenal glands, and low DHEA levels have also been linked to aging, lack of energy, lack of sex drive, etc. (Stephen Cherniske has written another book about DHEA: The DHEA Breakthrough)
"There is an intriguing but not fully understood connection between stress, caffeine, and autoimmune disorders such as rheumatoid arthritis, lupus, and MS." (p. 67, Caffeine Blues)
"The 'energy' you receive from caffeine is really just a loan from your adrenals and liver, and the interest is extremely high." (p. 64)
Caffeine causes adrenal exhaustion, i.e. the exhaustion of the adrenal glands. Adrenal exhaustion, in turn, has other consequences: "I was seeing patients every day with serious health problems that strong, healthy adrenals could have prevented. Why were these people vulnerable to allergy, inflammation, hypertension, infection, and fatigue?" (p. 65, Caffeine Blues)
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